もはや

1. 1No longer; not anymore. Used with a negative predicate to say that something once possible or present is now gone.Ex. 1
2. 2Already; by now. Used to state that a situation has already reached a certain, often undesirable, stage.

A written, somewhat formal adverb found in essays, news reports and serious speech. It often carries a sense that it is too late or that the earlier state is gone, and frequently appears with negatives or with expressions such as 手遅れ and 〜ようがない. In everyday conversation, もう is the natural choice for similar meanings.

• もうN5「もう」is a neutral expression used in both speech and writing; in the sense of "no longer" or "already" it can replace 「もはや」, though with a flatter tone. However, 「もう」can also express a completed action (「もう食べた」) or "again" (「もう一度」), and in those uses 「もはや」cannot be substituted.
• とっくにN2「とっくに」emphasizes that something happened or was completed long before a given point in time, usually attaching to the た form or ている form, and leans colloquial. 「もはや」instead stresses that a situation has passed a turning point and the outcome is settled; it is more written in style, is not used to simply report completion, and the two generally cannot be interchanged.
• 〜に至ってN1「もはや」is an adverb meaning "no longer / can no longer / has already become," while 「に至って」attaches to nouns or the dictionary form of a verb to indicate that only at a certain stage does something happen ("only then..."), often with 「ようやく」in the following clause. They cannot be interchanged.
• 一方だN3「一方だ」attaches to the dictionary form of a change verb and describes continuous change in one direction ("more and more..."), focusing on the process, whereas 「もはや」is an adverb stressing that the situation has passed a certain point, focusing on the result. 「一方だ」is neutral in register, and the two cannot be interchanged.
• ばかりだN2「ばかりだ」attaches to the dictionary form of a verb and shows a change continuing in the same direction ("more and more..."), while 「もはや」is an adverb indicating that things have reached a point where the situation is settled. The two cannot be interchanged, and 「ばかりだ」is neutral in register.

もう is the everyday, all-purpose word for 'already/no longer', whereas もはや is formal and stresses that a certain point has been passed; とっくに stresses that something happened long ago. 〜に至って marks the stage something has come to ('at the point of…'), and 一方だ/ばかりだ describe a continuing trend in one direction rather than a point already passed.